Product Description: mitochondrial import receptor subunit TOM40, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005742 | mitochondrial outer membrane translocase complex |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0008320 | protein transmembrane transporter activity |
| Process | GO:0030150 | protein import into mitochondrial matrix |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.10 | 0.95 |
| Trophozoite | no data | 0.19 | 0.89 |
| Schizont | no data | 0.02 | 0.99 |
| Gametocyte | no data | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0617000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.128 | MFS: -2.966 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT11
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101593
Most Similar Human Ortholog: Q969M1
TM-align score: 0.82 | RMSD: 2.16
Seq Identity: 0.16 | Length: 272 / 377
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130204 | translocase of outer mitochondrial membrane 40 |
| ENSG00000158882 | translocase of outer mitochondrial membrane 40 like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 16 | 10 | 15 |
| disruptive | 2 | 20 | 8 | 34 |
| missense | 2 | 20 | 8 | 29 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 38 | 13 | 14 |
| disruptive | 6 | 47 | 34 | 69 |
| missense | 6 | 40 | 30 | 38 |
PlasmoDB Total SNPs: 87
Non-coding: 75 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 377 | Molecular Weight (kDa): 43.624
UniProt ID(s): C6KT11
PDB ID(s): None
Isoelectric Point: 8.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR027246 | Eukaryotic porin/Tom40 |
| InterPro | IPR037930 | Tom40 |
| PFam | PF01459 | Eukaryotic porin/Tom40 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 27458014 | The Import of Proteins into the Mitochondrion of Toxoplasma gondii. | van Dooren GG, Yeoh LM, Striepen B, McFadden GI | 10.1074/jbc.M116.725069 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |