Product Description: AP-2 complex subunit alpha, putative
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030122 | AP-2 adaptor complex |
| Component | GO:0030130 | clathrin coat of trans-Golgi network vesicle |
| Function | GO:0140312 | cargo adaptor activity |
| Function | GO:0035615 | clathrin adaptor activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0072583 | clathrin-dependent endocytosis |
| Process | GO:0065003 | protein-containing complex assembly |
| Process | GO:0006898 | receptor-mediated endocytosis |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.75 | 0.65 |
| Trophozoite | expressed | 0.46 | 0.73 |
| Schizont | expressed | 0.64 | 0.64 |
| Gametocyte | expressed | 0.50 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0617100
Resistome Missense Mutations: H817P
Resistome Compounds with Missense Mutations: Artemisinin
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.819 | MFS: -2.939 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT12
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101447
Most Similar Human Ortholog: E9PQP4
TM-align score: 0.89 | RMSD: 1.32
Seq Identity: 0.21 | Length: 89 / 1236
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000183020 | adaptor related protein complex 2 subunit alpha 2 |
| ENSG00000196961 | adaptor related protein complex 2 subunit alpha 1 |
| ENSG00000280759 | adaptor related protein complex 2 subunit alpha 2 |
| ENSG00000281385 | adaptor related protein complex 2 subunit alpha 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 79 | 41 | 75 |
| disruptive | 29 | 69 | 37 | 131 |
| missense | 13 | 46 | 24 | 96 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 37 | 132 | 48 | 87 |
| disruptive | 50 | 198 | 111 | 341 |
| missense | 19 | 127 | 79 | 199 |
PlasmoDB Total SNPs: 365
Non-coding: 296 | Synonymous: 44 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 1236 | Molecular Weight (kDa): 145.364
UniProt ID(s): C6KT12
PDB ID(s): None
Isoelectric Point: 8.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| InterPro | IPR013041 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | PF01602 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| Superfamily | SSF49348 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 32098816 | The Plasmodium falciparum Artemisinin Susceptibility-Associated A P-2 Adaptin mu Subunit is Clathrin Independent and Essential for Schizont Maturation | Henrici RC, Edwards RL, ..., Sutherland CJ | 10.1128/mBio.02918-19 |