PF3D7_0617200

Genome location: Pf3D7_06_v3:714,972..720,182(+)

Genome classification: Core

Function and Localization

Product Description: BFR1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005783	endoplasmic reticulum
Component	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network
Component	GO:0005634	nucleus
Component	GO:1990904	ribonucleoprotein complex
Process	GO:0008298	intracellular mRNA localization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.89	0.61
Trophozoite	expressed	1.33	0.37
Schizont	expressed	0.50	0.69
Gametocyte	expressed	0.66	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0617200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.881 | MFS: -2.707 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1116800)

Relative Growth Rate: 0.14 ± 0.28
Confidence: 3.94

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT13

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105795

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	17	21	24
disruptive	4	14	11	28
missense	4	14	10	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	53	18	23
disruptive	13	47	34	93
missense	10	29	28	68

PlasmoDB Total SNPs: 194

Non-coding: 172 | Synonymous: 15 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 446 | Molecular Weight (kDa): 52.98

UniProt ID(s): C6KT13

PDB ID(s): None

Isoelectric Point: 9.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR039604	Nuclear segregation protein Bfr1
PFam	N/A	N/A
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
22144892	A systematic screen to discover and analyze apicoplast proteins identifies aconserved and essential protein import factor.	Sheiner L, Demerly JL, ..., Striepen B	10.1371/journal.ppat.1002392
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596