PF3D7_0617300

Genome location: Pf3D7_06_v3:720,336..721,721(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.02	0.99
Schizont	no data	0.08	0.95
Gametocyte	no data	0.05	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0617300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.923 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1116900)

Relative Growth Rate: 1.02 ± 0.18
Confidence: 4.83

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1116900)

Modification: Disrupted | RMgm-3019

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT14

"Best" AlphaFill ligand hit: CHD (cholic acid, Local RMSD=0.82) with 7EOV (Global RMSD=16.83)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127996

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	7	8	9
disruptive	1	5	1	6
missense	1	4	1	6

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	19	9	8
disruptive	3	18	14	36
missense	3	9	11	20

PlasmoDB Total SNPs: 104

Non-coding: 95 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 139 | Molecular Weight (kDa): 16.324

UniProt ID(s): C6KT14

PDB ID(s): None

Isoelectric Point: 9.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR035979	RNA-binding domain superfamily
PFam	N/A	N/A
Superfamily	SSF54928	RNA-binding domain superfamily