About Gene List

PF3D7_0617600

Genome location: Pf3D7_06_v3:738,020..739,535(-)

Genome classification: InternalHypervariable

Function and Localization

Product Description: stevor

SignalP Peptide: MNIYYVKILIFTFLVNTLILS

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0033644 host cell membrane
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.00 1.00
Trophozoite no data 0.00 1.00
Schizont no data 0.00 1.00
Gametocyte no data 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0617600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.997 | MFS: -2.16 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT16

"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=0.30) with 1ZCH (Global RMSD=18.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 306

Non-coding: 57 | Synonymous: 71 | Nonsynonymous: 178 | Stop Codon: 0

Protein Information

Protein Length: 302 | Molecular Weight (kDa): 33.958

UniProt ID(s): C6KT16

PDB ID(s): None

Isoelectric Point: 9

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006374 Variant surface antigen Stevor
PFam PF17410 Variant surface antigen Stevor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
12477793 Small variant STEVOR antigen is uniquely located within Maurer's clefts inPlasmodium falciparum-infected red blood cells. Kaviratne M, Khan SM, Jarra W, Preiser PR 10.1128/EC.1.6.926-935.2002
15961998 Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infectederythrocytes. Przyborski JM, Miller SK, ..., Lanzer M 10.1038/sj.emboj.7600720
25011110 STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. Niang M, Bei AK, ..., Preiser PR 10.1016/j.chom.2014.06.004
31363031 Dissecting the Gene Expression, Localization, Membrane Topology, and Function ofthe Plasmodium falciparum S TEVOR Protein Family Wichers JS, Scholz JAM, ..., Bachmann A 10.1128/mBio.01500-19