Product Description: histone H2A
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000786 | nucleosome |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Process | GO:0006325 | chromatin organization |
| Process | GO:0006342 | chromatin silencing |
| Process | GO:0051276 | chromosome organization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 1.84 | 0.37 |
| Trophozoite | no data | 4.36 | 0.05 |
| Schizont | no data | 5.63 | 0.00 |
| Gametocyte | no data | 3.81 | 0.02 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0617800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.363 | MFS: -2.378 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1117000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1117000)
Modification: Disrupted | RMgm-3020
More info: PhenoPlasm Link
AlphaFill Uniprot ID: P40282
"Best" AlphaFill ligand hit: IMT (4-amino-(1-methylimidazole)-2-carboxylic acid, Local RMSD=0.37) with 1S32 (Global RMSD=1.14)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100077
Most Similar Human Ortholog: Q93077
TM-align score: 0.91 | RMSD: 1.87
Seq Identity: 0.70 | Length: 129 / 132
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164508 | H2A clustered histone 1 |
| ENSG00000180573 | H2A clustered histone 6 |
| ENSG00000181218 | H2A.W histone |
| ENSG00000184260 | H2A clustered histone 20 |
| ENSG00000184270 | H2A clustered histone 21 |
| ENSG00000188486 | H2A.X variant histone |
| ENSG00000196747 | H2A clustered histone 13 |
| ENSG00000196787 | H2A clustered histone 11 |
| ENSG00000196866 | H2A clustered histone 7 |
| ENSG00000203812 | H2A clustered histone 18 |
| ENSG00000246705 | H2A.J histone |
| ENSG00000272196 | H2A clustered histone 19 |
| ENSG00000274997 | H2A clustered histone 12 |
| ENSG00000275221 | H2A clustered histone 15 |
| ENSG00000276368 | H2A clustered histone 14 |
| ENSG00000276903 | H2A clustered histone 16 |
| ENSG00000277075 | H2A clustered histone 8 |
| ENSG00000278463 | H2A clustered histone 4 |
| ENSG00000278677 | H2A clustered histone 17 |
| ENSG00000282988 | novel protein |
| ENSG00000284841 | H2A.W histone |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 90
Non-coding: 89 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 132 | Molecular Weight (kDa): 14.122
PDB ID(s): None
Isoelectric Point: 10.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002119 | Histone H2A |
| InterPro | IPR007125 | Histone H2A/H2B/H3 |
| InterPro | IPR009072 | Histone-fold |
| InterPro | IPR032454 | Histone H2A, C-terminal domain |
| InterPro | IPR032458 | Histone H2A conserved site |
| PFam | PF00125 | Histone H2A/H2B/H3 |
| PFam | PF16211 | Histone H2A, C-terminal domain |
| Superfamily | SSF47113 | Histone-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 20713134 | Plasmodium falciparum Tudor Staphylococcal Nuclease interacting proteins suggestits role in nuclear as well as splicing processes. | Hossain MJ, Korde R, ..., Malhotra P | 10.1016/j.gene.2010.08.004 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23320541 | H2A.Z/H2B.Z double-variant nucleosomes inhabit the AT-rich promoter regions ofthe Plasmodium falciparum genome. | Hoeijmakers WA, Salcedo-Amaya AM, ..., Bartfai R | 10.1111/mmi.12151 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 38366024 | Histone Variant H2A.Z and Linker Histone H1 Influence Chromosome Condensation inSaccharomyces cerevisiae | Rogers AM, Neri NR, Chigweshe L, Holmes SG | 10.1093/genetics/iyae022 |