Product Description: histone H3 variant
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000791 | euchromatin |
| Component | GO:0000786 | nucleosome |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0051276 | chromosome organization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 2.25 | 0.22 |
| Trophozoite | no data | 3.53 | 0.04 |
| Schizont | no data | 4.27 | 0.00 |
| Gametocyte | no data | 3.17 | 0.13 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0617900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.411 | MFS: -2.618 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1117100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1117100)
Modification: Disrupted | RMgm-3021
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT19
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P68431 | Histone H3.1 | HOGENOM | US9006242, 1US9006242, 2US9006242, 105US9006242, 1... |
Ortholog Group (OrthoMCL): OG6_100119
Most Similar Human Ortholog: Q71DI3
TM-align score: 0.94 | RMSD: 1.51
Seq Identity: 0.90 | Length: 136 / 136
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000163041 | H3.3 histone A |
| ENSG00000183598 | H3 clustered histone 13 |
| ENSG00000197153 | H3 clustered histone 12 |
| ENSG00000197409 | H3 clustered histone 4 |
| ENSG00000203811 | H3 clustered histone 14 |
| ENSG00000203852 | H3 clustered histone 15 |
| ENSG00000268799 | H3.Y histone 2 |
| ENSG00000269466 | H3.Y histone 1 |
| ENSG00000273213 | H3.2 histone (putative) |
| ENSG00000273983 | H3 clustered histone 8 |
| ENSG00000274750 | H3 clustered histone 6 |
| ENSG00000275379 | H3 clustered histone 11 |
| ENSG00000275714 | H3 clustered histone 1 |
| ENSG00000277775 | H3 clustered histone 7 |
| ENSG00000278828 | H3 clustered histone 10 |
| ENSG00000286522 | H3 clustered histone 2 |
| ENSG00000287080 | H3 clustered histone 3 |
Protein Length: 136 | Molecular Weight (kDa): 15.441
UniProt ID(s): C6KT19
PDB ID(s): None
Isoelectric Point: 11.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000164 | Histone H3/CENP-A |
| InterPro | IPR007125 | Histone H2A/H2B/H3 |
| InterPro | IPR009072 | Histone-fold |
| PFam | PF00125 | Histone H2A/H2B/H3 |
| Superfamily | SSF47113 | Histone-fold |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 210
Non-coding: 207 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27555062 | H3.3 demarcates GC-rich coding and subtelomeric regions and serves as potentialmemory mark for virulence gene expression in Plasmodium falciparum. | Fraschka SA, Henderson RW, Bartfai R | 10.1038/srep31965 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 32017676 | The chromatin bound proteome of the human malaria parasite | Batugedara G, Lu XM, ..., Le Roch KG | 10.1099/mgen.0.000327 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 38199522 | Histone H3.3 variant plays a critical role on zygote-to-oocyst development inmalaria parasites | Tateishi YS, Araki T, ..., Annoura T | 10.1016/j.parint.2024.102856 |