About Gene List

PF3D7_0618000

Genome location: Pf3D7_06_v3:757,278..761,654(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020020 food vacuole

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.11 0.94
Trophozoite not expressed 0.09 0.95
Schizont expressed 1.89 0.41
Gametocyte not expressed 0.10 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0618000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.308 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT20

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=4.61) with 7R8P (Global RMSD=18.78)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156640

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 22 26 41
disruptive 31 47 32 98
missense 15 43 30 85

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 71 27 59
disruptive 35 142 95 221
missense 16 116 72 128

PlasmoDB Total SNPs: 111

Non-coding: 58 | Synonymous: 34 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 795 | Molecular Weight (kDa): 92.755

UniProt ID(s): C6KT20

PDB ID(s): None

Isoelectric Point: 6.81

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
21136929 Food vacuole proteome of the malarial parasite Plasmodium falciparum. Lamarque M, Tastet C, ..., Dubremetz JF 10.1002/prca.200700112