PF3D7_0618100

Genome location: Pf3D7_06_v3:761,703..764,548(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.93
Trophozoite	expressed	0.42	0.75
Schizont	expressed	0.41	0.77
Gametocyte	expressed	0.52	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0618100

Resistome Missense Mutations: D373Y

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.057 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1117300)

Relative Growth Rate: 0.11 ± 0.06
Confidence: 7.08

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT21

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532488

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	37	15	35
disruptive	14	73	48	158
missense	14	71	48	147

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	65	32	37
disruptive	28	169	96	178
missense	23	153	89	148

PlasmoDB Total SNPs: 105

Non-coding: 69 | Synonymous: 19 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 743 | Molecular Weight (kDa): 89.505

UniProt ID(s): C6KT21

PDB ID(s): None

Isoelectric Point: 6.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A