Product Description: 60S ribosomal protein L27a, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 1.03 | 0.55 |
| Trophozoite | no data | 1.34 | 0.37 |
| Schizont | no data | 0.26 | 0.84 |
| Gametocyte | no data | 0.54 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0618300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.134 | MFS: -3.121 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT23
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100748
Most Similar Human Ortholog: P46776
TM-align score: 0.97 | RMSD: 0.76
Seq Identity: 0.66 | Length: 147 / 148
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000166441 | ribosomal protein L27a |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 101
Non-coding: 96 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 148 | Molecular Weight (kDa): 16.723
UniProt ID(s): C6KT23
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.23
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001196 | Ribosomal protein L15, conserved site |
| InterPro | IPR021131 | Ribosomal protein L18e/L15P |
| InterPro | IPR030878 | Ribosomal protein L15 |
| InterPro | IPR036227 | Ribosomal L18e/L15P superfamily |
| PFam | PF00828 | Ribosomal protein L18e/L15P |
| Superfamily | SSF52080 | Ribosomal L18e/L15P superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |