PF3D7_0618400

Genome location: Pf3D7_06_v3:770,147..772,506(-)

Genome classification: Core

Function and Localization

Product Description: LMBR1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0618400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.432 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1117600)

• Relative Growth Rate: 0.96 ± 0.20
• Confidence: 4.61

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1117600)

Modification: Disrupted | RMgm-3023

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT24

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106033

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 72

Non-coding: 38 | Synonymous: 15 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 598 | Molecular Weight (kDa): 71.484

UniProt ID(s): C6KT24

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations: