Product Description: malate dehydrogenase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.1.1.37 (Malate dehydrogenase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Function | GO:0030060 | L-malate dehydrogenase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.08 | 0.94 |
| Schizont | expressed | 0.10 | 0.92 |
| Gametocyte | expressed | 0.29 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0618500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.827 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1117700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1117700)
Modification: Disrupted | RMgm-3024
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT25
"Best" AlphaFill ligand hit: NAI (nadh, Local RMSD=0.19) with 4OKN (Global RMSD=2.58)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.1.1.37 | malate dehydrogenase | ATPADPCoAAMPNEMNAD+NADHEDTAcAMPDMSONADP+HgCl2... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q6VVP7 | L-lactate dehydrogenase | Plasmodium falciparum | OMA, OrthoMCL, OrthoMCL BLAST | Gossypol (C9)Oxamic acid derivative, 5Oxamic acid derivative, 7 |
| P00338 | L-lactate dehydrogenase A chain | Homo sapiens | OMA | CHEMBL3318412CHEMBL3318415CHEMBL3318469CHEMBL3358863... |
| P06151 | L-lactate dehydrogenase A chain | OMA | CHEMBL4081890CHEMBL4864519CHEMBL4873879CHEMBL4855986... | |
| P40926 | Malate dehydrogenase, mitochondrial | Homo sapiens | OrthoDB | CHEMBL427092CHEMBL3359141CHEMBL3359147CHEMBL427092... |
| B9UDZ5 | L-lactate dehydrogenase | Plasmodium falciparum | OrthoMCL BLAST | Gossypol (C9) |
| Q27743 | L-lactate dehydrogenase | Plasmodium falciparum | OrthoMCL BLAST | Gossypol (C9)Oxamic acid derivative, 5Oxamic acid derivative, 6Oxamic acid derivative, 7... |
Ortholog Group (OrthoMCL): OG6_101212
Most Similar Human Ortholog: P40926
TM-align score: 0.87 | RMSD: 1.88
Seq Identity: 0.24 | Length: 293 / 313
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000146701 | malate dehydrogenase 2 |
Protein Length: 313 | Molecular Weight (kDa): 34.041
PDB ID(s): 5NFR
Isoelectric Point: 7.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001236 | Lactate/malate dehydrogenase, N-terminal |
| InterPro | IPR001557 | L-lactate/malate dehydrogenase |
| InterPro | IPR011275 | Malate dehydrogenase, type 3 |
| InterPro | IPR015955 | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| InterPro | IPR022383 | Lactate/malate dehydrogenase, C-terminal |
| InterPro | IPR036291 | NAD(P)-binding domain superfamily |
| PFam | PF00056 | Lactate/malate dehydrogenase, N-terminal |
| PFam | PF02866 | Lactate/malate dehydrogenase, C-terminal |
| Superfamily | SSF51735 | NAD(P)-binding domain superfamily |
| Superfamily | SSF56327 | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 9 | 28 |
| disruptive | 1 | 8 | 0 | 14 |
| missense | 1 | 8 | 0 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 30 | 13 | 28 |
| disruptive | 2 | 19 | 13 | 56 |
| missense | 2 | 14 | 7 | 43 |
PlasmoDB Total SNPs: 90
Non-coding: 75 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 14598170 | Functional characterization of an alternative [lactate dehydrogenase-like] malatedehydrogenase in Plasmodium falciparum. | Chan M, Sim TS | 10.1007/s00436-003-0996-1 |
| 22684064 | Crystallization and preliminary X-ray diffraction of malate dehydrogenase fromPlasmodium falciparum. | Wrenger C, Muller IB, ..., Groves MR | 10.1107/S1744309112014571 |
| 38296006 | Selenium yeast improve growth, serum biochemical indices, metabolic ability,antioxidant capacity and immunity in black carp Mylopharyngodnpiceus | Zhang P, Zhang C, ..., Mi H | 10.1016/j.fsi.2024.109414 |