Product Description: trafficking protein particle complex subunit 6A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0030008 | TRAPP complex |
| Component | GO:0005801 | cis-Golgi network |
| Component | GO:0005634 | nucleus |
| Component | GO:0005802 | trans-Golgi network |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.21 | 0.90 |
| Trophozoite | no data | 0.59 | 0.66 |
| Schizont | no data | 0.18 | 0.88 |
| Gametocyte | no data | 0.55 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0618700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.376 | MFS: -3.589 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT27
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102793
Most Similar Human Ortholog: Q86SZ2
TM-align score: 0.85 | RMSD: 2.41
Seq Identity: 0.29 | Length: 157 / 284
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000182400 | trafficking protein particle complex 6B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 16 | 7 | 13 |
| disruptive | 7 | 30 | 20 | 59 |
| missense | 3 | 27 | 16 | 41 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 29 | 10 | 11 |
| disruptive | 16 | 91 | 46 | 96 |
| missense | 10 | 70 | 31 | 58 |
PlasmoDB Total SNPs: 58
Non-coding: 41 | Synonymous: 11 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 284 | Molecular Weight (kDa): 33.698
UniProt ID(s): C6KT27
PDB ID(s): None
Isoelectric Point: 5.05
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007194 | Transport protein particle (TRAPP) component |
| InterPro | IPR024096 | NO signalling/Golgi transport ligand-binding domain superfamily |
| InterPro | IPR037992 | TRAPP complex, Trs33 subunit |
| PFam | PF04051 | Transport protein particle (TRAPP) component |
| Superfamily | SSF111126 | NO signalling/Golgi transport ligand-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |