PF3D7_0618800

Genome location: Pf3D7_06_v3:779,480..783,561(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.06	0.97
Trophozoite	no data	0.51	0.70
Schizont	no data	0.17	0.88
Gametocyte	no data	0.56	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0618800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -3.169 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT28

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133807

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	42	32	64
disruptive	30	125	70	179
missense	12	89	63	148

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	95	47	85
disruptive	78	281	141	311
missense	35	205	112	230

PlasmoDB Total SNPs: 128

Non-coding: 53 | Synonymous: 49 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 1025 | Molecular Weight (kDa): 123.082

UniProt ID(s): C6KT28

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A