Product Description: FPL domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0036020 | endolysosome membrane |
| Component | GO:0016021 | integral component of membrane |
| Process | GO:0016197 | endosomal transport |
| Process | GO:0008333 | endosome to lysosome transport |
| Process | GO:1901096 | regulation of autophagosome maturation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | possibly expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0619000.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.135 | MFS: -3.131 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1118200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZX45
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=7.86) with 1MJH (Global RMSD=22.51)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103636
Most Similar Human Ortholog: Q2KHT3
TM-align score: 0.37 | RMSD: 7.38
Seq Identity: 0.18 | Length: 521 / 1796
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000038532 | C-type lectin domain containing 16A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 69 | 50 | 92 |
| disruptive | 65 | 183 | 128 | 251 |
| missense | 42 | 148 | 113 | 208 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 151 | 69 | 116 |
| disruptive | 123 | 389 | 203 | 370 |
| missense | 73 | 307 | 166 | 264 |
PlasmoDB Total SNPs: 511
Non-coding: 212 | Synonymous: 134 | Nonsynonymous: 165 | Stop Codon: 0
Protein Length: 1796 | Molecular Weight (kDa): 213.731
UniProt ID(s): C6KT30
PDB ID(s): None
Isoelectric Point: 4.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR019155 | CLEC16A/TT9, N-terminal |
| InterPro | IPR039272 | CLEC16A/TT9 |
| PFam | PF09758 | CLEC16A/TT9, N-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |