About Gene List

PF3D7_0619000

Genome location: Pf3D7_06_v3:788,061..796,075(-)

Genome classification: Core

Function and Localization

Product Description: FPL domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0036020 endolysosome membrane
Component GO:0016021 integral component of membrane
Process GO:0016197 endosomal transport
Process GO:0008333 endosome to lysosome transport
Process GO:1901096 regulation of autophagosome maturation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte possibly expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0619000.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -3.131 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1118200)

  • Relative Growth Rate: 0.11 ± 0.16
  • Confidence: 5.02

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZX45

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=7.86) with 1MJH (Global RMSD=22.51)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103636

Most Similar Human Ortholog: Q2KHT3

TM-align score: 0.37 | RMSD: 7.38

Seq Identity: 0.18 | Length: 521 / 1796

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000038532 C-type lectin domain containing 16A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 69 50 92
disruptive 65 183 128 251
missense 42 148 113 208

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 151 69 116
disruptive 123 389 203 370
missense 73 307 166 264

PlasmoDB Total SNPs: 511

Non-coding: 212 | Synonymous: 134 | Nonsynonymous: 165 | Stop Codon: 0

Protein Information

Protein Length: 1796 | Molecular Weight (kDa): 213.731

UniProt ID(s): C6KT30

PDB ID(s): None

Isoelectric Point: 4.92

Protein Domain Annotations:

Source Family ID Description
InterPro IPR016024 Armadillo-type fold
InterPro IPR019155 CLEC16A/TT9, N-terminal
InterPro IPR039272 CLEC16A/TT9
PFam PF09758 CLEC16A/TT9, N-terminal
Superfamily SSF48371 Armadillo-type fold

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104