About Gene List

PF3D7_0619200

Genome location: Pf3D7_06_v3:799,040..803,205(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.61 0.71
Trophozoite expressed 0.56 0.68
Schizont expressed 0.50 0.70
Gametocyte expressed 0.38 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0619200

Resistome Missense Mutations: D199N

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.188 | MFS: -2.779 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT32

"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=2.39) with 7DI7 (Global RMSD=21.98)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533654

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 41 37 82
disruptive 38 150 75 215
missense 26 143 73 196

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 117 48 77
disruptive 74 299 142 318
missense 51 268 127 246

PlasmoDB Total SNPs: 203

Non-coding: 124 | Synonymous: 36 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 1062 | Molecular Weight (kDa): 126.377

UniProt ID(s): C6KT32

PDB ID(s): None

Isoelectric Point: 5.87

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104