PF3D7_0619300

Genome location: Pf3D7_06_v3:802,988..814,565(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.94
Trophozoite	not expressed	1.01	0.50
Schizont	not expressed	0.42	0.77
Gametocyte	not expressed	1.52	0.39

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0619300

Resistome Missense Mutations: L415I, D1553G, N1777K, I1972V

Resistome Compounds with Missense Mutations: BCH070, BRD73842, Cipargamin/KAE609/NITD609, Primaquine

Resistome # Samples with Disruptive Mutations: 7 (5 missense, 3 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.913 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1118500)

Modification: Disrupted | RMgm-3027

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533689

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	30	179	101	217
disruptive	127	492	331	713
missense	84	421	286	608

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	60	327	144	244
disruptive	270	1135	489	970
missense	155	919	411	752

PlasmoDB Total SNPs: 501

Non-coding: 85 | Synonymous: 250 | Nonsynonymous: 164 | Stop Codon: 2

Protein Information

Protein Length: 3618 | Molecular Weight (kDa): 433.712

UniProt ID(s): C6KT33

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A