PF3D7_0619600

Genome location: Pf3D7_06_v3:824,758..828,098(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.04	0.98
Trophozoite	no data	0.27	0.84
Schizont	no data	0.04	0.98
Gametocyte	no data	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0619600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.148 | MFS: -2.836 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT36

"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=1.04) with 2JAT (Global RMSD=26.03)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533598

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	41	18	60
disruptive	40	130	57	175
missense	32	122	55	156

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	76	41	73
disruptive	68	273	125	285
missense	53	239	116	212

PlasmoDB Total SNPs: 146

Non-coding: 63 | Synonymous: 38 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 871 | Molecular Weight (kDa): 104.627

UniProt ID(s): C6KT36

PDB ID(s): None

Isoelectric Point: 8.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A