PF3D7_0619700

Genome location: Pf3D7_06_v3:828,122..830,389(-)

Genome classification: Core

Function and Localization

Product Description: F-box protein FBXO1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0070258	inner membrane pellicle complex
Component	GO:0048471	perinuclear region of cytoplasm
Process	GO:0051301	cell division

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.04	0.98
Trophozoite	no data	0.36	0.80
Schizont	no data	0.73	0.61
Gametocyte	no data	0.82	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0619700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.144 | MFS: -3.008 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1118900)

Modification: Disrupted | RMgm-5342

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT37

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122229

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	31	27	38
disruptive	7	47	34	72
missense	7	40	30	65

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	57	32	50
disruptive	22	138	79	183
missense	10	109	61	119

PlasmoDB Total SNPs: 105

Non-coding: 65 | Synonymous: 29 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 633 | Molecular Weight (kDa): 76.559

UniProt ID(s): C6KT37

PDB ID(s): None

Isoelectric Point: 9.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001810	F-box domain
PFam	PF00646	F-box domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
31348812	Toxoplasma F-box protein 1 is required for daughter cell scaffold function duringparasite replication.	Baptista CG, Lis A, ..., Blader IJ	10.1371/journal.ppat.1007946