Product Description: splicing factor 3A subunit 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0071004 | U2-type prespliceosome |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0005681 | spliceosomal complex |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000245 | spliceosomal complex assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.36 | 0.82 |
| Trophozoite | expressed | 0.45 | 0.73 |
| Schizont | expressed | 0.23 | 0.84 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0619900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.872 | #Insertions: 50
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1119100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT39
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102158
Most Similar Human Ortholog: K7EMT0
TM-align score: 0.54 | RMSD: 2.68
Seq Identity: 0.63 | Length: 93 / 233
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104897 | splicing factor 3a subunit 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 5 | 20 |
| disruptive | 1 | 4 | 4 | 19 |
| missense | 1 | 4 | 3 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 18 | 10 | 16 |
| disruptive | 4 | 16 | 14 | 43 |
| missense | 2 | 12 | 11 | 33 |
PlasmoDB Total SNPs: 88
Non-coding: 84 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 233 | Molecular Weight (kDa): 27.675
UniProt ID(s): C6KT39
PDB ID(s): None
Isoelectric Point: 10.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003604 | Matrin/U1-C-like, C2H2-type zinc finger |
| InterPro | IPR031781 | SF3A2 domain |
| InterPro | IPR036236 | Zinc finger C2H2 superfamily |
| PFam | PF12874 | SF3A2 domain |
| PFam | PF16835 | |
| Superfamily | SSF57667 | Zinc finger C2H2 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 8211113 | Correspondence between a mammalian spliceosome component and an essential yeastsplicing factor | Bennett M, Reed R | 10.1126/science.8211113 |