Genome location: Pf3D7_06_v3:841,846..843,363(-)
Genome classification: Core
Product Description: PIMMS43 protein
SignalP Peptide: MQKRIYVSLFFLVFFLSKISVVLS
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Process | GO:0044409 | entry into host |
| Process | GO:0042783 | evasion of host immune response |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | possibly expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0620000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.8 | MFS: -2.254 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1119200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1119200)
Modification: Mutated | RMgm-4826
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT40
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 4 | 29 |
| disruptive | 24 | 29 | 25 | 71 |
| missense | 23 | 25 | 23 | 62 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 25 | 13 | 35 |
| disruptive | 36 | 73 | 50 | 118 |
| missense | 28 | 61 | 43 | 95 |
PlasmoDB Total SNPs: 65
Non-coding: 0 | Synonymous: 40 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 505 | Molecular Weight (kDa): 59.604
UniProt ID(s): C6KT40
PDB ID(s): None
Isoelectric Point: 5.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 26018192 | Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-FamilyTranscription Factor. | Kaneko I, Iwanaga S, ..., Yuda M | 10.1371/journal.ppat.1004905 |
| 27083421 | Identification of three ookinete-specific genes and evaluation of theirtransmission-blocking potentials in Plasmodium berghei. | Zheng W, Kou X, ..., Cui L | 10.1016/j.vaccine.2016.04.011 |
| 27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |
| 32165544 | PIMMS43 is required for malaria parasite immune evasion and sporogonicdevelopment in the mosquito vector. | Ukegbu CV, Giorgalli M, ..., Vlachou D | 10.1073/pnas.1919709117 |