Genome location: Pf3D7_06_v3:845,162..846,452(+)
Genome classification: Core
Product Description: ATP synthase-associated protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.01 | 1.00 |
| Trophozoite | no data | 0.07 | 0.95 |
| Schizont | no data | 0.02 | 0.98 |
| Gametocyte | no data | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0620100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.435 | MFS: -3.773 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT41
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 5 | 2 | 6 |
| disruptive | 0 | 1 | 1 | 18 |
| missense | 0 | 1 | 1 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 11 | 3 | 8 |
| disruptive | 1 | 19 | 20 | 47 |
| missense | 0 | 11 | 18 | 35 |
PlasmoDB Total SNPs: 17
Non-coding: 14 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 130 | Molecular Weight (kDa): 15.509
UniProt ID(s): C6KT41
PDB ID(s): None
Isoelectric Point: 10
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30005062 | Highly diverged novel subunit composition of apicomplexan F-type ATP synthaseidentified from Toxoplasma gondii. | Salunke R, Mourier T, ..., Shanmugam D | 10.1371/journal.pbio.2006128 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |