PF3D7_0620200

Genome location: Pf3D7_06_v3:846,523..848,013(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.01	1.00
Schizont	no data	0.06	0.96
Gametocyte	no data	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0620200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -2.852 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT42

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532603

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	4	9
disruptive	7	16	11	35
missense	4	12	10	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	15	12	19
disruptive	10	60	29	73
missense	6	41	26	48

PlasmoDB Total SNPs: 80

Non-coding: 17 | Synonymous: 37 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 323 | Molecular Weight (kDa): 39.043

UniProt ID(s): C6KT42

PDB ID(s): None

Isoelectric Point: 7.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A