PF3D7_0620300

Genome location: Pf3D7_06_v3:848,035..850,864(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.04	0.98
Trophozoite	no data	0.11	0.93
Schizont	no data	0.53	0.70
Gametocyte	no data	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0620300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.946 | MFS: -2.644 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT43

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532731

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	32	19	55
disruptive	18	93	71	156
missense	18	89	68	139

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	62	37	66
disruptive	31	252	130	274
missense	25	211	116	179

PlasmoDB Total SNPs: 56

Non-coding: 20 | Synonymous: 19 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 819 | Molecular Weight (kDa): 98.971

UniProt ID(s): C6KT43

PDB ID(s): None

Isoelectric Point: 9.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A