Product Description: merozoite surface protein 10
SignalP Peptide: MMFFKCNQVFTLVFLLLLYFNNIVYT
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0046658 | anchored component of plasma membrane |
| Function | GO:0046812 | host cell surface binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | not expressed | 0.05 | 0.97 |
| Schizont | expressed | 1.24 | 0.46 |
| Gametocyte | not expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0620400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.347 | MFS: -2.675 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1119600)
Modification: Other | RMgm-416
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT44
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 13 | 14 | 19 |
| disruptive | 58 | 93 | 43 | 95 |
| missense | 36 | 55 | 26 | 69 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 29 | 15 | 26 |
| disruptive | 88 | 171 | 73 | 153 |
| missense | 49 | 109 | 52 | 105 |
PlasmoDB Total SNPs: 126
Non-coding: 33 | Synonymous: 45 | Nonsynonymous: 48 | Stop Codon: 0
Protein Length: 525 | Molecular Weight (kDa): 61.381
UniProt ID(s): C5HDU1, C5HDU4, C5HDU6, C5HDU7, C5HDU8, C5HDU9, C5HDV0, C5HDV5, C5HDV6, C5HDV7, C6KT44, Q868T5, Q868T6, Q868T9, Q868U1, Q868U4
PDB ID(s): None
Isoelectric Point: 4.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR024731 | EGF domain |
| PFam | PF12947 | EGF domain |
| Superfamily | SSF57196 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15820753 | Identifying Plasmodium falciparum merozoite surface protein-10 human erythrocytespecific binding regions. | Puentes A, Ocampo M, ..., Patarroyo ME | 10.1016/j.biochi.2005.01.001 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16603573 | Identification and stoichiometry of glycosylphosphatidylinositol-anchoredmembrane proteins of the human malaria parasite Plasmodium falciparum. | Gilson PR, Nebl T, ..., Crabb BS | 10.1074/mcp.M600035-MCP200 |
| 26174014 | Isolation, production and characterization of fully human monoclonal antibodiesdirected to Plasmodium falciparum MSP10. | Maskus DJ, Bethke S, ..., Fendel R | 10.1186/s12936-015-0797-x |
| 31547821 | Evaluation of Plasmodium falciparum MSP10 and its development as a serologicaltool for the Peruvian Amazon region | Bendezu J, Villasis E, ..., Torres K | 10.1186/s12936-019-2959-8 |
| 27347876 | Evolution of the Transmission-Blocking Vaccine Candidates Pvs28 and Pvs25 inPlasmodium vivax: Geographic Differentiation and Evidence of Positive Selection | Chaurio RA, Pacheco MA, ..., Escalante AA | 10.1371/journal.pntd.0004786 |
| 31952523 | A panel of recombinant proteins from human-infective Plasmodium species forserological surveillance | Muller-Sienerth N, Shilts J, ..., Wright GJ | 10.1186/s12936-020-3111-5 |
| 27828953 | Correction: Colorimetric Detection of Plasmodium vivax in Urine Using MSP10Oligonucleotides and Gold Nanoparticles | Alnasser Y, Ferradas C, ..., Gilman RH | 10.1371/journal.pntd.0005143 |
| 31770108 | Anti-MSP-10 IgG indicates recent exposure to Plasmodium vivax infection in thePeruvian Amazon | Rosas-Aguirre A, Patra KP, ..., Vinetz JM | 10.1172/jci.insight.130769 |
| 21182986 | Low genetic polymorphism of merozoite surface proteins 7 and 10 in ColombianPlasmodium vivax isolates | Garzon-Ospina D, Romero-Murillo L, Tobon LF, Patarroyo MA | 10.1016/j.meegid.2010.12.002 |
| 31824483 | The N-Terminal Region of Plasmodium falciparum MSP10 Is a Target of ProtectiveAntibodies in Malaria and Is Important for PfGAMA/PfMSP10 Interaction | Nagaoka H, Kanoi BN, ..., Takashima E | 10.3389/fimmu.2019.02669 |
| 29037202 | High prevalence of very-low Plasmodium falciparum and Plasmodium vivaxparasitaemia carriers in the Peruvian Amazon: insights into local andoccupational mobility-related transmission | Carrasco-Escobar G, Miranda-Alban J, ..., Vinetz JM | 10.1186/s12936-017-2063-x |
| 27706158 | Colorimetric Detection of Plasmodium vivax in Urine Using MSP10 Oligonucleotidesand Gold Nanoparticles | Alnasser Y, Ferradas C, ..., Gilman RH | 10.1371/journal.pntd.0005029 |
| 28532483 | Naturally acquired humoral and cellular immune responses to Plasmodium vivaxmerozoite surface protein 8 in patients with P. vivax infection | Cheng Y, Wang B, ..., Han ET | 10.1186/s12936-017-1837-5 |
| 22414917 | Evidence of purifying selection on merozoite surface protein 8 (MSP8) and 10(MSP10) in Plasmodium spp | Pacheco MA, Elango AP, ..., Escalante AA | 10.1016/j.meegid.2012.02.009 |
| 30995911 | Hospital-derived antibody profiles of malaria patients in Southwest India | Venkatesh A, Jain A, ..., Rathod PK | 10.1186/s12936-019-2771-5 |