Product Description: cleavage stimulation factor subunit 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005848 | mRNA cleavage stimulating factor complex |
| Function | GO:0003723 | RNA binding |
| Process | GO:0006396 | RNA processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.47 | 0.77 |
| Trophozoite | no data | 0.71 | 0.60 |
| Schizont | no data | 0.43 | 0.75 |
| Gametocyte | no data | 0.38 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0620500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.171 | MFS: -2.737 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1119700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1119700)
Modification: Disrupted | RMgm-3033
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT45
"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.09) with 4GM3 (Global RMSD=10.47)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103995
Most Similar Human Ortholog: Q05048
TM-align score: 0.71 | RMSD: 3.27
Seq Identity: 0.22 | Length: 337 / 650
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101138 | cleavage stimulation factor subunit 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 29 | 22 | 39 |
| disruptive | 28 | 87 | 48 | 93 |
| missense | 17 | 75 | 40 | 82 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 58 | 27 | 50 |
| disruptive | 43 | 177 | 94 | 174 |
| missense | 29 | 146 | 76 | 118 |
PlasmoDB Total SNPs: 111
Non-coding: 49 | Synonymous: 29 | Nonsynonymous: 33 | Stop Codon: 0
Protein Length: 650 | Molecular Weight (kDa): 76.492
UniProt ID(s): C6KT45
PDB ID(s): None
Isoelectric Point: 4.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |