PF3D7_0620700

Genome location: Pf3D7_06_v3:858,689..860,721(-)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion
Process	GO:0042407	cristae formation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.06	0.97
Trophozoite	possibly expressed	0.28	0.83
Schizont	possibly expressed	1.11	0.43
Gametocyte	expressed	0.95	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0620700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.18 | MFS: -3.42 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT47

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.92) with 8BNS (Global RMSD=12.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139470

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	10	9	28
disruptive	8	31	23	49
missense	8	30	20	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	28	22	23
disruptive	14	78	42	115
missense	12	63	37	71

PlasmoDB Total SNPs: 99

Non-coding: 78 | Synonymous: 11 | Nonsynonymous: 8 | Stop Codon: 2

Protein Information

Protein Length: 362 | Molecular Weight (kDa): 42.792

UniProt ID(s): C6KT47

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR024586	DnaJ-like protein C11, C-terminal
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	PF11875	DnaJ-like protein C11, C-terminal
Superfamily	SSF46565	Chaperone J-domain superfamily