About Gene List

PF3D7_0621100

Genome location: Pf3D7_06_v3:865,550..870,507(-)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite not expressed 0.15 0.90
Schizont expressed 1.12 0.48
Gametocyte expressed 0.46 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0621100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.171 | MFS: -2.756 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1120100)

  • Relative Growth Rate: 0.90 ± 0.10
  • Confidence: 5.92

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1120100)

Modification: Disrupted | RMgm-3034

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT49

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129591

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 65 35 76
disruptive 30 132 78 197
missense 23 119 71 176

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 138 56 81
disruptive 64 284 129 314
missense 44 238 115 242

PlasmoDB Total SNPs: 186

Non-coding: 74 | Synonymous: 63 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 1354 | Molecular Weight (kDa): 159.359

UniProt ID(s): C6KT49

PDB ID(s): None

Isoelectric Point: 7.14

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
PFam N/A N/A
Superfamily SSF48452 Tetratricopeptide-like helical domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095