About Gene List

PF3D7_0621350 (SYS1)

Genome location: Pf3D7_06_v3:876,679..877,298(-)

Genome classification: Core

Function and Localization

Product Description: protein SYS1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030173 integral component of Golgi membrane
Component GO:0016021 integral component of membrane
Component GO:0005802 trans-Golgi network
Process GO:0006895 Golgi to endosome transport
Process GO:0043001 Golgi to plasma membrane protein transport
Process GO:0034067 protein localization to Golgi apparatus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.00 1.00
Trophozoite no data 0.00 1.00
Schizont no data 0.11 0.93
Gametocyte no data 0.10 0.94

More info:

Resistome Mutations

No corresponding Pf3D7v3 gene ID in resistome database

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.451 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZY25

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103385

Most Similar Human Ortholog: Q8N2H4

TM-align score: 0.87 | RMSD: 1.82

Seq Identity: 0.18 | Length: 134 / 138

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000204070 SYS1 golgi trafficking protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 11 4 11
disruptive 3 12 9 32
missense 3 10 7 25

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 15 7 14
disruptive 7 35 29 36
missense 6 27 20 27

PlasmoDB Total SNPs: 0

Non-coding: 0 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 138 | Molecular Weight (kDa): 16.49

UniProt ID(s): A0A143ZY25

PDB ID(s): None

Isoelectric Point: 7.81

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019185 Integral membrane protein SYS1-related
PFam PF09801 Integral membrane protein SYS1-related
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
27555049 Microscopy-based Saccharomyces cerevisiae complementation model revealsfunctional conservation and redundancy of N-terminal acetyltransferases Osberg C, Aksnes H, ..., Arnesen T 10.1038/srep31627
36519157 Investigation the global effect of rare earth gadolinium on the buddingSaccharomyces cerevisiae by genome-scale screening Cao Y, Zhang C, ..., Wang X 10.3389/fmicb.2022.1022054