PF3D7_0621400 (ALV7)

Genome location: Pf3D7_06_v3:878,363..880,852(+)

Genome classification: Core

Function and Localization

Product Description: Pf77 protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0070258	inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.10	0.95
Trophozoite	possibly expressed	0.03	0.98
Schizont	possibly expressed	0.21	0.87
Gametocyte	expressed	0.94	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0621400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.829 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1120400)

Relative Growth Rate: 0.98 ± 0.17
Confidence: 4.90

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1120400)

Modification: Disrupted | RMgm-3036

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT52

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131670

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	34	23	32
disruptive	17	62	42	85
missense	16	57	39	70

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	62	32	36
disruptive	36	121	58	188
missense	28	104	54	123

PlasmoDB Total SNPs: 144

Non-coding: 91 | Synonymous: 31 | Nonsynonymous: 21 | Stop Codon: 1

Protein Information

Protein Length: 664 | Molecular Weight (kDa): 77.454

UniProt ID(s): C6KT52, Q27435

PDB ID(s): None

Isoelectric Point: 4.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022086	Inner membrane complex protein
PFam	PF12314	Inner membrane complex protein
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
18359944	Alveolins, a new family of cortical proteins that define the protist infrakingdomAlveolata.	Gould SB, Tham WH, ..., Waller RF	10.1093/molbev/msn070