Product Description: ribonuclease P/MRP protein subunit RPP1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.26.5 (Ribonuclease P)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005655 | nucleolar ribonuclease P complex |
| Component | GO:0000172 | ribonuclease MRP complex |
| Component | GO:0030677 | ribonuclease P complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0004540 | ribonuclease activity |
| Process | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
| Process | GO:0008033 | tRNA processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.50 | 0.71 |
| Schizont | expressed | 0.36 | 0.77 |
| Gametocyte | possibly expressed | 0.46 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0621500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.16 | MFS: -3.206 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1120500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1120500)
Modification: Disrupted | RMgm-3037
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT53
"Best" AlphaFill ligand hit: 144 (tris-hydroxymethyl-methyl-ammonium, Local RMSD=2.20) with 4FE2 (Global RMSD=17.03)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.26.5 | ribonuclease P | ATPRNAEDTANH4+tRNASO42-NeoR5NeoG6NeoK6retinolneaminemat-tRNA... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102854
Most Similar Human Ortholog: P78346
TM-align score: 0.76 | RMSD: 3.03
Seq Identity: 0.18 | Length: 240 / 343
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148688 | ribonuclease P/MRP subunit p30 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 1 | 20 |
| disruptive | 7 | 27 | 18 | 39 |
| missense | 7 | 27 | 16 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 23 | 8 | 21 |
| disruptive | 11 | 64 | 30 | 72 |
| missense | 10 | 54 | 27 | 56 |
PlasmoDB Total SNPs: 33
Non-coding: 22 | Synonymous: 4 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 343 | Molecular Weight (kDa): 40.288
UniProt ID(s): C6KT53
PDB ID(s): None
Isoelectric Point: 8.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002738 | RNase P subunit p30 |
| InterPro | IPR016195 | Polymerase/histidinol phosphatase-like |
| PFam | PF01876 | RNase P subunit p30 |
| Superfamily | SSF89550 | Polymerase/histidinol phosphatase-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 36760653 | Analysis of the role of BrRPP1 gene in Chinese cabbage infected by Plasmodiophorabrassicae | Ge W, Lv M, ..., Ji R | 10.3389/fpls.2023.1082395 |