PF3D7_0621700

Genome location: Pf3D7_06_v3:884,024..890,267(+)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.93
Trophozoite	not expressed	0.61	0.67
Schizont	not expressed	0.10	0.94
Gametocyte	not expressed	0.77	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0621700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -3.17 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT54

"Best" AlphaFill ligand hit: SFG (sinefungin, Local RMSD=4.71) with 7RFK (Global RMSD=15.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127466

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	70	45	101
disruptive	33	155	95	241
missense	23	142	88	208

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	137	68	104
disruptive	68	345	168	347
missense	44	291	143	252

PlasmoDB Total SNPs: 256

Non-coding: 130 | Synonymous: 96 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 1616 | Molecular Weight (kDa): 192.026

UniProt ID(s): C6KT54

PDB ID(s): None

Isoelectric Point: 7.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	N/A	N/A
Superfamily	N/A	N/A