Product Description: nascent polypeptide-associated complex subunit alpha, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005854 | nascent polypeptide-associated complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0051083 | 'de novo' cotranslational protein folding |
| Process | GO:0006612 | protein targeting to membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.46 | 0.78 |
| Trophozoite | no data | 0.57 | 0.70 |
| Schizont | no data | 0.05 | 0.97 |
| Gametocyte | no data | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0621800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.159 | MFS: -2.92 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT55
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101216
Most Similar Human Ortholog: F8VNW4
TM-align score: 0.51 | RMSD: 3.42
Seq Identity: 0.33 | Length: 90 / 184
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000196531 | nascent polypeptide associated complex subunit alpha |
| ENSG00000253506 | nascent polypeptide associated complex subunit alpha 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 2 | 6 |
| disruptive | 1 | 3 | 2 | 12 |
| missense | 1 | 3 | 2 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 20 | 3 | 20 |
| disruptive | 2 | 13 | 14 | 48 |
| missense | 1 | 9 | 12 | 32 |
PlasmoDB Total SNPs: 91
Non-coding: 86 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 184 | Molecular Weight (kDa): 20.623
UniProt ID(s): C6KT55
PDB ID(s): None
Isoelectric Point: 4.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002715 | Nascent polypeptide-associated complex NAC domain |
| InterPro | IPR016641 | Nascent polypeptide-associated complex subunit alpha |
| InterPro | IPR044034 | Nascent polypeptide-associated complex subunit alpha-like, UBA domain |
| PFam | PF01849 | Nascent polypeptide-associated complex NAC domain |
| PFam | PF19026 | Nascent polypeptide-associated complex subunit alpha-like, UBA domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |