PF3D7_0621900 (SRP68)

Genome location: Pf3D7_06_v3:892,883..896,208(-)

Genome classification: Core

Function and Localization

Product Description: signal recognition particle subunit SRP68, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Component	GO:0005786	signal recognition particle, endoplasmic reticulum targeting
Function	GO:0003723	RNA binding
Function	GO:0005047	signal recognition particle binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.13	0.50
Trophozoite	expressed	1.18	0.41
Schizont	possibly expressed	0.38	0.77
Gametocyte	not expressed	0.66	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0621900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.905 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1120800)

Relative Growth Rate: 0.17 ± 0.36
Confidence: 3.45

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT56

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_163241

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	46	30	38
disruptive	22	66	45	100
missense	11	60	42	86

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	82	29	54
disruptive	42	147	85	184
missense	25	119	67	145

PlasmoDB Total SNPs: 118

Non-coding: 49 | Synonymous: 48 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 776 | Molecular Weight (kDa): 92.452

UniProt ID(s): C6KT56

PDB ID(s): None

Isoelectric Point: 8.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026258	Signal recognition particle subunit SRP68
PFam	N/A	N/A
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
33906926	Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH	Sinha A, Baumgarten S, ..., Scherf A	10.1128/mBio.00661-21
24434517	Plasmodium falciparum signal recognition particle components and anti-parasiticeffect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP	Panchal M, Rawat K, ..., Tuteja R	10.1038/cddis.2013.521
18768469	Role of protein translocation pathways across the endoplasmic reticulum inTrypanosoma brucei	Goldshmidt H, Sheiner L, ..., Michaeli S	10.1074/jbc.M801499200
17715370	Down-regulation of the trypanosomatid signal recognition particle affects thebiogenesis of polytopic membrane proteins but not of signal peptide-containingproteins	Lustig Y, Vagima Y, ..., Michaeli S	10.1128/EC.00134-07