PF3D7_0622000

Genome location: Pf3D7_06_v3:896,664..897,983(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MNHVSLLLLSIILFSYIFVRG

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.13	0.93
Trophozoite	no data	0.33	0.82
Schizont	no data	0.11	0.93
Gametocyte	no data	0.23	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0622000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.255 | MFS: -2.71 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT57

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532557

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	4	7	9
disruptive	6	14	15	23
missense	6	13	15	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	14	12	10
disruptive	8	48	22	55
missense	8	37	19	40

PlasmoDB Total SNPs: 106

Non-coding: 99 | Synonymous: 3 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 212 | Molecular Weight (kDa): 25.74

UniProt ID(s): C6KT57

PDB ID(s): None

Isoelectric Point: 9.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A