PF3D7_0622300

Genome location: Pf3D7_06_v3:907,610..911,239(+)

Genome classification: Core

Function and Localization

Product Description: vacuolar transporter chaperone, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.09	0.96
Trophozoite	possibly expressed	0.20	0.88
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0622300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.89 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1121200)

Relative Growth Rate: 1.01 ± 0.13
Confidence: 5.41

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1121200)

Modification: Disrupted | RMgm-4628

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT60

"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.11) with 3G3U (Global RMSD=2.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106806

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	33	23	49
disruptive	17	69	41	101
missense	11	61	32	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	70	39	61
disruptive	37	159	76	203
missense	17	125	60	132

PlasmoDB Total SNPs: 150

Non-coding: 100 | Synonymous: 35 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 834 | Molecular Weight (kDa): 99.812

UniProt ID(s): C6KT60

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018966	VTC domain
PFam	PF09359	VTC domain
Superfamily	N/A	N/A