About Gene List

PF3D7_0622600 (QCR9)

Genome location: Pf3D7_06_v3:914,409..915,450(+)

Genome classification: Core

Function and Localization

Product Description: cytochrome b-c1 complex subunit 9, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: 1.10.2.2 (Transferred entry: 7.1.1.8)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005750 mitochondrial respiratory chain complex III
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.01 0.99
Trophozoite no data 0.11 0.93
Schizont no data 0.14 0.91
Gametocyte no data 0.08 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0622600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.127 | MFS: -3.102 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1121500)

  • Relative Growth Rate: 0.19 ± 0.25
  • Confidence: 4.19

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4H6

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
1.10.2.2 quinol-cytochrome-c reductase No BRENDA inhibitors

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139435

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 5 3 5
disruptive 2 1 1 7
missense 2 0 1 7

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 9 5 6
disruptive 3 10 6 15
missense 2 7 5 12

PlasmoDB Total SNPs: 26

Non-coding: 22 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 96 | Molecular Weight (kDa): 11.696

UniProt ID(s): C0H4H6

PDB ID(s): None

Isoelectric Point: 9.8

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008027 Cytochrome b-c1 complex subunit 9
InterPro IPR036656 Cytochrome b-c1 complex subunit 9 superfamily
PFam PF05365 Cytochrome b-c1 complex subunit 9
Superfamily SSF81514 Cytochrome b-c1 complex subunit 9 superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
33524071 Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex inToxoplasma gondii parasites. Hayward JA, Rajendran E, ..., van Dooren GG 10.1371/journal.ppat.1009211
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21
7668049 SSU71, encoding the largest subunit of TFIIF, is located on the right arm ofchromosome VII in Saccharomyces cerevisiae Sun ZW, Hampsey M 10.1002/yea.320110811
25435378 Enhanced hexose fermentation by Saccharomyces cerevisiae through integration ofstoichiometric modeling and genetic screening Quarterman J, Kim SR, Kim PJ, Jin YS 10.1016/j.jbiotec.2014.11.017
1651316 The petite phenotype resulting from a truncated copy of subunit 6 results fromloss of assembly of the cytochrome bc1 complex and can be suppressed byoverexpression of subunit 9 Schmitt ME, Trumpower BL https://pubmed.ncbi.nlm.nih.gov/1651316/
12384503 A pathogenic cytochrome b mutation reveals new interactions between subunits ofthe mitochondrial bc1 complex Saint-Georges Y, Bonnefoy N, ..., Dujardin G 10.1074/jbc.M207219200
8389362 Subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex is required forinsertion of EPR-detectable iron-sulfur cluster into the Rieske iron-sulfurprotein Phillips JD, Graham LA, Trumpower BL https://pubmed.ncbi.nlm.nih.gov/8389362/
19236481 Evidence that the assembly of the yeast cytochrome bc1 complex involves theformation of a large core structure in the inner mitochondrial membrane Zara V, Conte L, Trumpower BL 10.1111/j.1742-4658.2009.06916.x
8382892 QCR9, the nuclear gene encoding a small subunit of the mitochondrial cytochromebc1 complex, maps to the right arm of chromosome VII in Saccharomyces cerevisiae Phillips JD, Trumpower BL 10.1002/yea.320090112
10873857 Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeastSaccharomyces cerevisiae co-crystallized with an antibody Fv fragment Hunte C, Koepke J, ..., Michel H 10.1016/s0969-2126(00)00152-0
19175415 The influence of yeast oxygenation prior to brewery fermentation on yeastmetabolism and the oxidative stress response Verbelen PJ, Depraetere SA, ..., Delvaux F 10.1111/j.1567-1364.2008.00476.x
8544831 Mode of action of the qcr9 and cat3 mutations in restoring the ability ofSaccharomyces cerevisiae tps1 mutants to grow on glucose Blazquez MA, Gancedo C 10.1007/BF00418035
22535436 Transcriptome analysis identifies genes involved in ethanol response ofSaccharomyces cerevisiae in Agave tequilana juice Ramirez-Cordova J, Drnevich J, ..., Alvarez-Maya I 10.1007/s10482-012-9733-z
9133739 DNA sequence analysis of a 23,002 bp DNA fragment of the right arm ofSaccharomyces cerevisiae chromosome VII Arroyo J, Garcia-Gonzalez M, ..., Nombela C 10.1002/(SICI)1097-0061(19970330)13:4<357::AID-YEA77>3.0.CO;2-J
11102369 The oxen gene of Drosophila encodes a homolog of subunit 9 of yeastubiquinol-cytochrome c oxidoreductase complex: evidence for modulation of geneexpression in response to mitochondrial activity Frolov MV, Benevolenskaya EV, Birchler JA 10.1093/genetics/156.4.1727
1332881 Deletion of subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complexspecifically impairs electron transfer at the ubiquinol oxidase site (center P)in the bc1 complex Graham LA, Phillips JD, Trumpower BL 10.1016/0014-5793(92)81203-x
2174427 Isolation and characterization of QCR9, a nuclear gene encoding the 7.3-kDasubunit 9 of the Saccharomyces cerevisiae ubiquinol-cytochrome c oxidoreductasecomplex. An intron-containing gene with a conserved sequence occurring in theintron of COX4 Phillips JD, Schmitt ME, ..., Trumpower BL https://pubmed.ncbi.nlm.nih.gov/2174427/
8771716 ERG1, encoding squalene epoxidase, is located on the right arm of chromosome VIIof Saccharomyces cerevisiae Landl KM, Klosch B, Turnowsky F 10.1002/(SICI)1097-0061(199605)12:6<609::AID-YEA949>3.0.CO;2-B