Product Description: cytochrome b-c1 complex subunit 9, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 1.10.2.2 (Transferred entry: 7.1.1.8)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005750 | mitochondrial respiratory chain complex III |
Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | no data | N/A | N/A |
Ring | no data | 0.01 | 0.99 |
Trophozoite | no data | 0.11 | 0.93 |
Schizont | no data | 0.14 | 0.91 |
Gametocyte | no data | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0622600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.127 | MFS: -3.102 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1121500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4H6
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
1.10.2.2 | quinol-cytochrome-c reductase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 5 | 3 | 5 |
disruptive | 2 | 1 | 1 | 7 |
missense | 2 | 0 | 1 | 7 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 9 | 5 | 6 |
disruptive | 3 | 10 | 6 | 15 |
missense | 2 | 7 | 5 | 12 |
PlasmoDB Total SNPs: 26
Non-coding: 22 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 96 | Molecular Weight (kDa): 11.696
UniProt ID(s): C0H4H6
PDB ID(s): None
Isoelectric Point: 9.8
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR008027 | Cytochrome b-c1 complex subunit 9 |
InterPro | IPR036656 | Cytochrome b-c1 complex subunit 9 superfamily |
PFam | PF05365 | Cytochrome b-c1 complex subunit 9 |
Superfamily | SSF81514 | Cytochrome b-c1 complex subunit 9 superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
33524071 | Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex inToxoplasma gondii parasites. | Hayward JA, Rajendran E, ..., van Dooren GG | 10.1371/journal.ppat.1009211 |
34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
7668049 | SSU71, encoding the largest subunit of TFIIF, is located on the right arm ofchromosome VII in Saccharomyces cerevisiae | Sun ZW, Hampsey M | 10.1002/yea.320110811 |
25435378 | Enhanced hexose fermentation by Saccharomyces cerevisiae through integration ofstoichiometric modeling and genetic screening | Quarterman J, Kim SR, Kim PJ, Jin YS | 10.1016/j.jbiotec.2014.11.017 |
1651316 | The petite phenotype resulting from a truncated copy of subunit 6 results fromloss of assembly of the cytochrome bc1 complex and can be suppressed byoverexpression of subunit 9 | Schmitt ME, Trumpower BL | https://pubmed.ncbi.nlm.nih.gov/1651316/ |
12384503 | A pathogenic cytochrome b mutation reveals new interactions between subunits ofthe mitochondrial bc1 complex | Saint-Georges Y, Bonnefoy N, ..., Dujardin G | 10.1074/jbc.M207219200 |
8389362 | Subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex is required forinsertion of EPR-detectable iron-sulfur cluster into the Rieske iron-sulfurprotein | Phillips JD, Graham LA, Trumpower BL | https://pubmed.ncbi.nlm.nih.gov/8389362/ |
19236481 | Evidence that the assembly of the yeast cytochrome bc1 complex involves theformation of a large core structure in the inner mitochondrial membrane | Zara V, Conte L, Trumpower BL | 10.1111/j.1742-4658.2009.06916.x |
8382892 | QCR9, the nuclear gene encoding a small subunit of the mitochondrial cytochromebc1 complex, maps to the right arm of chromosome VII in Saccharomyces cerevisiae | Phillips JD, Trumpower BL | 10.1002/yea.320090112 |
10873857 | Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeastSaccharomyces cerevisiae co-crystallized with an antibody Fv fragment | Hunte C, Koepke J, ..., Michel H | 10.1016/s0969-2126(00)00152-0 |
19175415 | The influence of yeast oxygenation prior to brewery fermentation on yeastmetabolism and the oxidative stress response | Verbelen PJ, Depraetere SA, ..., Delvaux F | 10.1111/j.1567-1364.2008.00476.x |
8544831 | Mode of action of the qcr9 and cat3 mutations in restoring the ability ofSaccharomyces cerevisiae tps1 mutants to grow on glucose | Blazquez MA, Gancedo C | 10.1007/BF00418035 |
22535436 | Transcriptome analysis identifies genes involved in ethanol response ofSaccharomyces cerevisiae in Agave tequilana juice | Ramirez-Cordova J, Drnevich J, ..., Alvarez-Maya I | 10.1007/s10482-012-9733-z |
9133739 | DNA sequence analysis of a 23,002 bp DNA fragment of the right arm ofSaccharomyces cerevisiae chromosome VII | Arroyo J, Garcia-Gonzalez M, ..., Nombela C | 10.1002/(SICI)1097-0061(19970330)13:4<357::AID-YEA77>3.0.CO;2-J |
11102369 | The oxen gene of Drosophila encodes a homolog of subunit 9 of yeastubiquinol-cytochrome c oxidoreductase complex: evidence for modulation of geneexpression in response to mitochondrial activity | Frolov MV, Benevolenskaya EV, Birchler JA | 10.1093/genetics/156.4.1727 |
1332881 | Deletion of subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complexspecifically impairs electron transfer at the ubiquinol oxidase site (center P)in the bc1 complex | Graham LA, Phillips JD, Trumpower BL | 10.1016/0014-5793(92)81203-x |
2174427 | Isolation and characterization of QCR9, a nuclear gene encoding the 7.3-kDasubunit 9 of the Saccharomyces cerevisiae ubiquinol-cytochrome c oxidoreductasecomplex. An intron-containing gene with a conserved sequence occurring in theintron of COX4 | Phillips JD, Schmitt ME, ..., Trumpower BL | https://pubmed.ncbi.nlm.nih.gov/2174427/ |
8771716 | ERG1, encoding squalene epoxidase, is located on the right arm of chromosome VIIof Saccharomyces cerevisiae | Landl KM, Klosch B, Turnowsky F | 10.1002/(SICI)1097-0061(199605)12:6<609::AID-YEA949>3.0.CO;2-B |