About Gene List

PF3D7_0622900 (AP2Tel)

Genome location: Pf3D7_06_v3:924,060..932,959(-)

Genome classification: Core

Function and Localization

Product Description: AP2 domain transcription factor AP2Tel

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000781 chromosome, telomeric region
Component GO:0034399 nuclear periphery
Function GO:0003677 DNA binding
Function GO:0042162 telomeric DNA binding
Process GO:0006355 regulation of transcription, DNA-templated

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 2.51 0.15
Trophozoite possibly expressed 0.98 0.51
Schizont possibly expressed 0.98 0.51
Gametocyte not expressed 1.07 0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0622900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.111 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1123200)

Modification: Disrupted | RMgm-4394

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT65

"Best" AlphaFill ligand hit: C5P (cytidine-5'-monophosphate, Local RMSD=1.63) with 8A0C (Global RMSD=23.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532608

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 72 60 128
disruptive 54 294 173 409
missense 38 267 153 356

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 183 94 143
disruptive 133 686 276 605
missense 87 570 230 447

PlasmoDB Total SNPs: 383

Non-coding: 162 | Synonymous: 141 | Nonsynonymous: 79 | Stop Codon: 1

Protein Information

Protein Length: 1989 | Molecular Weight (kDa): 237.367

UniProt ID(s): C6KT65

PDB ID(s): None

Isoelectric Point: 9.29

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
28376558 Pf AP2Tel, harbouring a non-canonical D NA-binding A P2 domain, binds to Plasmodiumfalciparum telomeres Sierra-Miranda M, Vembar SS, ..., Hernandez-Rivas R 10.1111/cmi.12742