Product Description: nuclear polyadenylated RNA-binding protein NAB2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0008143 | poly(A) binding |
| Process | GO:1900364 | negative regulation of mRNA polyadenylation |
| Process | GO:0043488 | regulation of mRNA stability |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.73 | 0.65 |
| Trophozoite | expressed | 0.82 | 0.56 |
| Schizont | expressed | 0.20 | 0.87 |
| Gametocyte | expressed | 0.64 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0623100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.488 | MFS: -2.519 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1122000)
Modification: Tagged | RMgm-5091
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT67
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_106005
Most Similar Human Ortholog: G3V2X4
TM-align score: 0.80 | RMSD: 1.50
Seq Identity: 0.29 | Length: 61 / 786
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100722 | zinc finger CCCH-type containing 14 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 41 | 29 | 43 |
| disruptive | 38 | 111 | 62 | 129 |
| missense | 16 | 87 | 56 | 123 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 79 | 36 | 49 |
| disruptive | 64 | 225 | 111 | 225 |
| missense | 33 | 190 | 99 | 150 |
PlasmoDB Total SNPs: 509
Non-coding: 421 | Synonymous: 46 | Nonsynonymous: 42 | Stop Codon: 0
Protein Length: 786 | Molecular Weight (kDa): 91.145
UniProt ID(s): C6KT67
PDB ID(s): None
Isoelectric Point: 9.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR040366 | Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 |
| PFam | PF14608 | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34604117 | Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage ofMalaria Parasites. | Niikura M, Fukutomi T, Mitobe J, Kobayashi F | 10.3389/fcimb.2021.737457 |