Product Description: superoxide dismutase [Fe]
SignalP Peptide: MNLKILLCSSIFLFFLKPNVPKGAYG
# Transmembrane Domains: 0
EC Numbers: 1.15.1.1 (Superoxide dismutase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004784 | superoxide dismutase activity |
| Process | GO:0019430 | removal of superoxide radicals |
| Process | GO:0006979 | response to oxidative stress |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.04 | 0.98 |
| Trophozoite | possibly expressed | 0.13 | 0.91 |
| Schizont | possibly expressed | 0.06 | 0.95 |
| Gametocyte | possibly expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0623500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.174 | MFS: -3.224 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1422700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1122400)
Modification: Disrupted | RMgm-3050
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT71
"Best" AlphaFill ligand hit: PMS (phenylmethanesulfonic acid, Local RMSD=0.09) with 1WB8 (Global RMSD=6.67)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.15.1.1 | superoxide dismutase | BRENDA SOAP query unsuccessful |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q4DCQ3 | Superoxide dismutase | OrthoDB | CHEMBL4127450CHEMBL4128846CHEMBL4129006 |
Ortholog Group (OrthoMCL): OG6_100280
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 266
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112096 | superoxide dismutase 2 |
Protein Length: 266 | Molecular Weight (kDa): 31.293
PDB ID(s): None
Isoelectric Point: 8.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001189 | Manganese/iron superoxide dismutase |
| InterPro | IPR019831 | Manganese/iron superoxide dismutase, N-terminal |
| InterPro | IPR019832 | Manganese/iron superoxide dismutase, C-terminal |
| InterPro | IPR019833 | Manganese/iron superoxide dismutase, binding site |
| InterPro | IPR036314 | Manganese/iron superoxide dismutase, C-terminal domain superfamily |
| InterPro | IPR036324 | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
| PFam | PF00081 | Manganese/iron superoxide dismutase, N-terminal |
| PFam | PF02777 | Manganese/iron superoxide dismutase, C-terminal |
| Superfamily | SSF46609 | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
| Superfamily | SSF54719 | Manganese/iron superoxide dismutase, C-terminal domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 13 | 8 | 18 |
| disruptive | 6 | 20 | 14 | 34 |
| missense | 6 | 20 | 14 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 28 | 9 | 14 |
| disruptive | 7 | 57 | 23 | 74 |
| missense | 7 | 49 | 20 | 63 |
PlasmoDB Total SNPs: 121
Non-coding: 104 | Synonymous: 9 | Nonsynonymous: 8 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15279958 | Identification of a mitochondrial superoxide dismutase with an unusual targetingsequence in Plasmodium falciparum. | Sienkiewicz N, Daher W, ..., Khalife J | 10.1016/j.molbiopara.2004.05.005 |
| 17784785 | Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and theapicoplast of Toxoplasma gondii. | Pino P, Foth BJ, ..., Soldati-Favre D | 10.1371/journal.ppat.0030115 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |