Product Description: splicing factor-like protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000375 | RNA splicing, via transesterification reactions |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.18 | 0.91 |
| Trophozoite | expressed | 0.21 | 0.87 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.19 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0623600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.985 | MFS: -2.573 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1122500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT72
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q17339 | Female germline-specific tumor suppressor gld-1 | Caenorhabditis elegans | OrthoDB | MLS000077061MLS000030943diacetylrheinMLS000057573... |
Ortholog Group (OrthoMCL): OG6_102013
Most Similar Human Ortholog: C9J792
TM-align score: 0.55 | RMSD: 3.23
Seq Identity: 0.37 | Length: 49 / 615
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000168066 | splicing factor 1 |
Protein Length: 615 | Molecular Weight (kDa): 70.426
UniProt ID(s): C6KT72
PDB ID(s): None
Isoelectric Point: 6.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001878 | Zinc finger, CCHC-type |
| InterPro | IPR004087 | K Homology domain |
| InterPro | IPR004088 | K Homology domain, type 1 |
| InterPro | IPR031150 | BBP/SF1 family |
| InterPro | IPR032570 | Splicing factor 1, helix-hairpin domain |
| InterPro | IPR036612 | K Homology domain, type 1 superfamily |
| InterPro | IPR036875 | Zinc finger, CCHC-type superfamily |
| PFam | PF00013 | K Homology domain, type 1 |
| PFam | PF16275 | Splicing factor 1, helix-hairpin domain |
| Superfamily | SSF54791 | K Homology domain, type 1 superfamily |
| Superfamily | SSF57756 | Zinc finger, CCHC-type superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 32 | 19 | 49 |
| disruptive | 4 | 43 | 31 | 84 |
| missense | 3 | 42 | 30 | 78 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 76 | 34 | 33 |
| disruptive | 15 | 123 | 53 | 151 |
| missense | 11 | 108 | 46 | 114 |
PlasmoDB Total SNPs: 182
Non-coding: 165 | Synonymous: 12 | Nonsynonymous: 5 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22681889 | The mRNA-bound proteome and its global occupancy profile on protein-codingtranscripts. | Baltz AG, Munschauer M, ..., Landthaler M | 10.1016/j.molcel.2012.05.021 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |