Product Description: ATP-dependent RNA helicase SUV3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.4.13 (RNA helicase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045025 | mitochondrial degradosome |
| Function | GO:0003724 | RNA helicase activity |
| Process | GO:0006401 | RNA catabolic process |
| Process | GO:0016070 | RNA metabolic process |
| Process | GO:0000965 | mitochondrial RNA 3'-end processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.34 | 0.83 |
| Trophozoite | expressed | 0.32 | 0.81 |
| Schizont | possibly expressed | 0.13 | 0.91 |
| Gametocyte | expressed | 0.34 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0623700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.9 | MFS: -2.929 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1122600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT73
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.03) with 3RC3 (Global RMSD=0.98)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.4.13 | RNA helicase | ATPADPUDPAMPGTPGDPUTPKClNEMCDPITPTDP... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q8IYB8 | ATP-dependent RNA helicase SUPV3L1, mitochondrial | OrthoDB | CHEMBL2112136 |
Ortholog Group (OrthoMCL): OG6_101922
Most Similar Human Ortholog: B1AR60
TM-align score: 0.69 | RMSD: 3.15
Seq Identity: 0.34 | Length: 207 / 1137
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000156502 | Suv3 like RNA helicase |
Protein Length: 1137 | Molecular Weight (kDa): 136.286
UniProt ID(s): C6KT73
PDB ID(s): None
Isoelectric Point: 8.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001650 | Helicase, C-terminal |
| InterPro | IPR022192 | Mitochondrial degradasome RNA helicase subunit, C-terminal domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00271 | Helicase, C-terminal |
| PFam | PF12513 | Mitochondrial degradasome RNA helicase subunit, C-terminal domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 70 | 32 | 79 |
| disruptive | 41 | 148 | 80 | 171 |
| missense | 29 | 141 | 72 | 152 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 132 | 48 | 93 |
| disruptive | 81 | 298 | 143 | 246 |
| missense | 55 | 253 | 122 | 197 |
PlasmoDB Total SNPs: 142
Non-coding: 26 | Synonymous: 65 | Nonsynonymous: 51 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 32152734 | Ccm1p is a 15S rRNA primary transcript processing factor as elucidated by a novelin vivo system in Saccharomyces cerevisiae | Moreno JI, Coleman IS, ..., Piva MA | 10.1007/s00294-020-01064-0 |