Product Description: tyrosine kinase-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.10.2 (Non-specific protein-tyrosine kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0004672 | protein kinase activity |
| Function | GO:0004674 | protein serine/threonine kinase activity |
| Process | GO:0006468 | protein phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 3.01 | 0.10 |
| Trophozoite | expressed | 0.94 | 0.54 |
| Schizont | expressed | 0.65 | 0.66 |
| Gametocyte | expressed | 0.88 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0623800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.685 | #Insertions: 2
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1122700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1122700)
Modification: Disrupted | RMgm-3053
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6KT74
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.01) with 5WE8 (Global RMSD=6.50)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.10.2 | non-specific protein-tyrosine kinase | ADPPP1PP2T47ChkCskPIP2CMP6RNAiWASPmorinAG490... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 53 | 140 | 68 | 135 |
| disruptive | 133 | 458 | 222 | 455 |
| missense | 56 | 322 | 171 | 356 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 75 | 255 | 107 | 163 |
| disruptive | 244 | 886 | 359 | 682 |
| missense | 106 | 644 | 281 | 422 |
PlasmoDB Total SNPs: 637
Non-coding: 319 | Synonymous: 195 | Nonsynonymous: 122 | Stop Codon: 1
Protein Length: 2404 | Molecular Weight (kDa): 279.784
UniProt ID(s): C6KT74
PDB ID(s): None
Isoelectric Point: 7.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000719 | Protein kinase domain |
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | PF00069 | Protein kinase domain |
| Superfamily | SSF48371 | Armadillo-type fold |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |