PF3D7_0624200

Genome location: Pf3D7_06_v3:984,837..986,998(-)

Genome classification: Core

Function and Localization

Product Description: SURP domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0000395	mRNA 5'-splice site recognition

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.29	0.82
Schizont	not expressed	0.21	0.86
Gametocyte	not expressed	0.89	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0624200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.72 | MFS: -0.314 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1123100)

Relative Growth Rate: 1.00 ± 0.20
Confidence: 4.57

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1123100)

Modification: Disrupted | RMgm-4255

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT78

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=1.17) with 3M6A (Global RMSD=10.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532806

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	23	11	26
disruptive	5	44	19	79
missense	5	44	18	74

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	40	16	24
disruptive	12	101	45	103
missense	10	91	41	83

PlasmoDB Total SNPs: 57

Non-coding: 40 | Synonymous: 10 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 341 | Molecular Weight (kDa): 40.904

UniProt ID(s): C6KT78

PDB ID(s): None

Isoelectric Point: 6.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR035967	SWAP/Surp superfamily
InterPro	IPR040397	Suppressor of white apricot
PFam	N/A	N/A
Superfamily	SSF109905	SWAP/Surp superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104