PF3D7_0624300

Genome location: Pf3D7_06_v3:987,808..989,636(+)

Genome classification: Core

Function and Localization

Product Description: CPW-WPC family protein

SignalP Peptide: MNYLSSFFCLILFLLYLNFCAC

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.02	0.99
Schizont	no data	0.03	0.98
Gametocyte	no data	0.87	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0624300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.565 | MFS: -2.48 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT79

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160729

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	7	7	12
disruptive	4	21	9	20
missense	4	20	9	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	22	13	8
disruptive	8	34	26	57
missense	7	29	20	37

PlasmoDB Total SNPs: 131

Non-coding: 118 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 185 | Molecular Weight (kDa): 22.109

UniProt ID(s): C6KT79

PDB ID(s): None

Isoelectric Point: 9.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006387	CPW-WPC domain
PFam	PF09717	CPW-WPC domain
Superfamily	N/A	N/A