PF3D7_0624400

Genome location: Pf3D7_06_v3:989,930..992,253(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MIPFYFFFFLLAFICIKKSDE

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.25	0.88
Trophozoite	expressed	0.87	0.54
Schizont	expressed	0.36	0.78
Gametocyte	expressed	0.78	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0624400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.318 | MFS: -3.396 | #Insertions: 0

PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_1123300)

Relative Growth Rate: 0.52 ± 0.62
Confidence: 2.33

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT80

"Best" AlphaFill ligand hit: TYD (thymidine-5'-diphosphate, Local RMSD=0.09) with 5TPV (Global RMSD=23.78)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533563

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	25	20	38
disruptive	14	72	43	97
missense	13	67	40	88

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	61	36	42
disruptive	31	157	70	157
missense	23	138	59	117

PlasmoDB Total SNPs: 107

Non-coding: 36 | Synonymous: 46 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 607 | Molecular Weight (kDa): 73.114

UniProt ID(s): C6KT80

PDB ID(s): None

Isoelectric Point: 9.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895