PF3D7_0624500 (APC11)

Genome location: Pf3D7_06_v3:993,658..996,430(+)

Genome classification: Core

Function and Localization

Product Description: anaphase-promoting complex subunit 11, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005680	anaphase-promoting complex
Component	GO:0031461	cullin-RING ubiquitin ligase complex
Component	GO:0005634	nucleus
Function	GO:0097602	cullin family protein binding
Function	GO:0061630	ubiquitin protein ligase activity
Process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition
Process	GO:0016567	protein ubiquitination
Process	GO:0006511	ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.02	0.99
Trophozoite	expressed	0.14	0.91
Schizont	expressed	0.35	0.78
Gametocyte	expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0624500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.888 | MFS: -2.97 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT81

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103498

Most Similar Human Ortholog: Q9NYG5

TM-align score: 0.82 | RMSD: 2.13

Seq Identity: 0.35 | Length: 82 / 89

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000141552	anaphase promoting complex subunit 11

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 171

Non-coding: 168 | Synonymous: 0 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 89 | Molecular Weight (kDa): 10.211

UniProt ID(s): C6KT81

PDB ID(s): None

Isoelectric Point: 8.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024991	Anaphase-promoting complex subunit 11
PFam	PF12861	Anaphase-promoting complex subunit 11
Superfamily	SSF57850	N/A