PF3D7_0624800

Genome location: Pf3D7_06_v3:1,011,429..1,014,569(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MWFGYNILAITTFGLLIRRGHA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0624800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.834 | MFS: -2.137 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1123700)

Modification: Disrupted | RMgm-107

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT84

"Best" AlphaFill ligand hit: DGT (2'-deoxyguanosine-5'-triphosphate, Local RMSD=0.83) with 6BRK (Global RMSD=13.87)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532989

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	30	11	21
disruptive	31	57	34	77
missense	29	55	31	68

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	44	20	36
disruptive	48	130	62	147
missense	43	97	49	108

PlasmoDB Total SNPs: 181

Non-coding: 119 | Synonymous: 34 | Nonsynonymous: 26 | Stop Codon: 2

Protein Information

Protein Length: 624 | Molecular Weight (kDa): 75.118

UniProt ID(s): C6KT84

PDB ID(s): None

Isoelectric Point: 9.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A