About Gene List

PF3D7_0625200

Genome location: Pf3D7_06_v3:1,024,810..1,026,740(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.03 0.98
Trophozoite no data 0.29 0.82
Schizont no data 0.32 0.79
Gametocyte no data 0.39 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0625200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.149 | MFS: -2.955 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT88

"Best" AlphaFill ligand hit: TMO (trimethylamine oxide, Local RMSD=0.04) with 5WLQ (Global RMSD=5.30)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533182

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 17 6 22
disruptive 11 44 22 71
missense 8 43 20 58

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 30 13 32
disruptive 30 114 51 125
missense 21 92 43 89

PlasmoDB Total SNPs: 93

Non-coding: 69 | Synonymous: 9 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 385 | Molecular Weight (kDa): 45.601

UniProt ID(s): C6KT88

PDB ID(s): None

Isoelectric Point: 9.07

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104