PF3D7_0625400

Genome location: Pf3D7_06_v3:1,031,969..1,034,471(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKFFVLFLLVTLNLFHISLE

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.84	0.63
Trophozoite	no data	0.22	0.88
Schizont	no data	0.24	0.88
Gametocyte	no data	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0625400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.076 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KT90

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532824

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	18	21	16
disruptive	9	51	29	69
missense	8	47	26	59

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	40	15	20
disruptive	24	115	70	131
missense	15	99	59	81

PlasmoDB Total SNPs: 225

Non-coding: 200 | Synonymous: 16 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 412 | Molecular Weight (kDa): 48.544

UniProt ID(s): C6KT90

PDB ID(s): None

Isoelectric Point: 5.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A